6AZI
1.75 Angstrom Resolution Crystal Structure of D-alanyl-D-alanine Endopeptidase from Enterobacter cloacae in Complex with Covalently Bound Boronic Acid
Summary for 6AZI
| Entry DOI | 10.2210/pdb6azi/pdb |
| Descriptor | D-alanyl-D-alanine endopeptidase, BORATE ION (3 entities in total) |
| Functional Keywords | structural genomics, center for structural genomics of infectious diseases, csgid, d-alanyl-d-alanine endopeptidase, boronic acid., hydrolase |
| Biological source | Enterobacter cloacae subsp. cloacae ATCC 13047 |
| Total number of polymer chains | 1 |
| Total formula weight | 31936.68 |
| Authors | Minasov, G.,Wawrzak, Z.,Shuvalova, L.,Kiryukhina, O.,Dubrovska, I.,Grimshaw, S.,Kwon, K.,Anderson, W.F.,Satchell, K.J.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2017-09-11, release date: 2017-10-04, Last modification date: 2025-06-18) |
| Primary citation | Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F. Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria. Microbiol Resour Announc, :e0020025-e0020025, 2025 Cited by PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications. PubMed: 40391899DOI: 10.1128/mra.00200-25 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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