6AYB

Naegleria fowleri CYP51-ketoconazole complex

Summary for 6AYB

Entry DOI	10.2210/pdb6ayb/pdb
Related	5TL8 6AY4 6AY6
Descriptor	CYP51, sterol 14alpha-demethylase, PROTOPORPHYRIN IX CONTAINING FE, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	cyp51, sterol 14alpha-demethylase, oxidoreductase
Biological source	Naegleria fowleri
Total number of polymer chains	1
Total formula weight	55090.33
Authors	Debnath, A.,Calvet, C.M.,Jennings, G.,Zhou, W.,Aksenov, A.,Luth, M.,Abagyan, R.,Nes, W.D.,McKerrow, J.H.,Podust, L.M. (deposition date: 2017-09-08, release date: 2017-11-22, Last modification date: 2023-11-15)
Primary citation	Debnath, A.,Calvet, C.M.,Jennings, G.,Zhou, W.,Aksenov, A.,Luth, M.R.,Abagyan, R.,Nes, W.D.,McKerrow, J.H.,Podust, L.M. CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). PLoS Negl Trop Dis, 11:e0006104-e0006104, 2017 Cited by PubMed: 29284029 DOI: 10.1371/journal.pntd.0006104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation