6AVT
STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.5 WITH CROSS-LINKING TO FIRST BASE TEMPLATE OVERHANG
Summary for 6AVT
Entry DOI | 10.2210/pdb6avt/pdb |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT, DNA (27-MER), ... (8 entities in total) |
Functional Keywords | rt, dna, crosslink, n site complex, d4t (stavudine), pyrophosphorolysis, p51, p66, transferase-dna complex, transcription-dna complex, transferase/dna |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 8 |
Total formula weight | 263617.69 |
Authors | Martinez, S.E.,Das, K.,Arnold, E. (deposition date: 2017-09-04, release date: 2018-08-15, Last modification date: 2023-10-04) |
Primary citation | Martinez, S.E.,Bauman, J.D.,Das, K.,Arnold, E. Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes. Protein Sci., 28:587-597, 2019 Cited by PubMed: 30499174DOI: 10.1002/pro.3559 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.603 Å) |
Structure validation
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