6AVO
Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively inhibits activated lymphocytes
Summary for 6AVO
Entry DOI | 10.2210/pdb6avo/pdb |
EMDB information | 7010 |
Descriptor | Proteasome subunit beta type-9, Proteasome subunit alpha type-2, Proteasome subunit beta type-1, ... (15 entities in total) |
Functional Keywords | inhibitor, complex, immunoproteasome, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 28 |
Total formula weight | 716690.06 |
Authors | Li, H.,Santos, R.,Bai, L. (deposition date: 2017-09-04, release date: 2017-12-06, Last modification date: 2024-03-13) |
Primary citation | Santos, R.L.A.,Bai, L.,Singh, P.K.,Murakami, N.,Fan, H.,Zhan, W.,Zhu, Y.,Jiang, X.,Zhang, K.,Assker, J.P.,Nathan, C.F.,Li, H.,Azzi, J.,Lin, G. Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes. Nat Commun, 8:1692-1692, 2017 Cited by PubMed: 29167449DOI: 10.1038/s41467-017-01760-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
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