6AVO

Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively inhibits activated lymphocytes

6AVO の概要

• エントリーDOI: 10.2210/pdb6avo/pdb
• EMDBエントリー: 7010
• 分子名称: Proteasome subunit beta type-9, Proteasome subunit alpha type-2, Proteasome subunit beta type-1, ... (15 entities in total)
• 機能のキーワード: inhibitor, complex, immunoproteasome, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 716690.06

構造登録者

Li, H.,Santos, R.,Bai, L. (登録日: 2017-09-04, 公開日: 2017-12-06, 最終更新日: 2024-03-13)

• 主引用文献: Santos, R.L.A.,Bai, L.,Singh, P.K.,Murakami, N.,Fan, H.,Zhan, W.,Zhu, Y.,Jiang, X.,Zhang, K.,Assker, J.P.,Nathan, C.F.,Li, H.,Azzi, J.,Lin, G.; Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.; Nat Commun, 8:1692-1692, 2017; PubMed: 29167449; DOI: 10.1038/s41467-017-01760-5

実験手法

ELECTRON MICROSCOPY (3.8 Å)