6AU3
Crystal structure of SETDB1 Tudor domain with aryl triazole fragments
Summary for 6AU3
Entry DOI | 10.2210/pdb6au3/pdb |
Descriptor | Histone-lysine N-methyltransferase SETDB1, N-{[2-(3,5-dimethyl-4H-1,2,4-triazol-4-yl)phenyl]methyl}acetamide, SULFATE ION, ... (6 entities in total) |
Functional Keywords | setdb1 tudor, fragment hits, epigenetics, methyllysine reader, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: Q15047 |
Total number of polymer chains | 1 |
Total formula weight | 25578.37 |
Authors | MADER, P.,Mendoza-Sanchez, R.,IQBAL, A.,DONG, A.,DOBROVETSKY, E.,CORLESS, V.B.,LIEW, S.K.,TEMPEL, W.,SMIL, D.,DELA SENA, C.C.,KENNEDY, S.,DIAZ, D.,HOLOWNIA, A.,VEDADI, M.,BROWN, P.J.,SANTHAKUMAR, V.,Bountra, C.,Edwards, A.M.,YUDIN, A.K.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC) (deposition date: 2017-08-30, release date: 2017-09-27, Last modification date: 2024-03-13) |
Primary citation | MADER, P.,Mendoza-Sanchez, R.,IQBAL, A.,DONG, A.,DOBROVETSKY, E.,CORLESS, V.B.,LIEW, S.K.,TEMPEL, W.,SMIL, D.,DELA SENA, C.C.,KENNEDY, S.,DIAZ, D.,HOLOWNIA, A.,VEDADI, M.,BROWN, P.J.,SANTHAKUMAR, V.,Bountra, C.,Edwards, A.M.,YUDIN, A.K.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC) Crystal structure of SETDB1 Tudor domain with aryl triazole fragments to be published, |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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