6AU0
Crystal structure of PPK2 (Class III) in complex with bisphosphonate inhibitor (2-((3,5-dichlorophenyl)amino)ethane-1,1-diyl)diphosphonic acid
Summary for 6AU0
Entry DOI | 10.2210/pdb6au0/pdb |
Descriptor | Polyphosphate:AMP phosphotransferase, {[(3,5-dichlorophenyl)amino]methylene}bis(phosphonic acid), GLYCEROL, ... (4 entities in total) |
Functional Keywords | ppk2, kinase, bisphosphonate inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469) |
Total number of polymer chains | 1 |
Total formula weight | 36097.71 |
Authors | Nocek, B.,Ruszkowski, M.,Joachimiak, A.,Berlicki, L.,Yakunin, A. (deposition date: 2017-08-29, release date: 2019-01-16, Last modification date: 2024-03-13) |
Primary citation | Nocek, B.,Khusnutdinova, A.N.,Ruszkowski, M.,Flick, R.,Burda, M.,Batyrova, K.,Brown, G.,Mucha, A.,Joachimiak, A.,Berlicki, L.,Yakunin, A.F. Structural Insights into Substrate Selectivity and Activity of Bacterial Polyphosphate Kinases Acs Catalysis, 8:10746-10760, 2018 Cited by DOI: 10.1021/acscatal.8b03151PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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