6ATT
39S Fab bound to HER2 ecd
Summary for 6ATT
Entry DOI | 10.2210/pdb6att/pdb |
Descriptor | Receptor tyrosine-protein kinase erbB-2, Antibody 39S Fab heavy chain, Antibody 39S Fab light chain, ... (5 entities in total) |
Functional Keywords | antibody, fragment antigen binding, her2, receptor, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 118521.35 |
Authors | Oganesyan, V.Y.,Dall'Acqua, W.F. (deposition date: 2017-08-29, release date: 2018-04-25, Last modification date: 2023-10-04) |
Primary citation | Oganesyan, V.,Peng, L.,Bee, J.S.,Li, J.,Perry, S.R.,Comer, F.,Xu, L.,Cook, K.,Senthil, K.,Clarke, L.,Rosenthal, K.,Gao, C.,Damschroder, M.,Wu, H.,Dall'Acqua, W. Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody. J. Biol. Chem., 293:8439-8448, 2018 Cited by PubMed: 29669810DOI: 10.1074/jbc.M117.818013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.77 Å) |
Structure validation
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