6ARV

Crystal structure of CARM1 with Compound 2 and SAH

6ARV の概要

• エントリーDOI: 10.2210/pdb6arv/pdb
• 分子名称: Histone-arginine methyltransferase CARM1, S-ADENOSYL-L-HOMOCYSTEINE, (2R)-1-amino-3-{3-[4-(morpholin-4-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]phenoxy}propan-2-ol, ... (5 entities in total)
• 機能のキーワード: protein-inhibitor complex, protein arginine methyltransferase, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: Q86X55
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 162689.15

構造登録者

Boriack-Sjodin, P.A.,Jin, L. (登録日: 2017-08-23, 公開日: 2018-02-07, 最終更新日: 2024-03-13)

• 主引用文献: Drew, A.E.,Moradei, O.,Jacques, S.L.,Rioux, N.,Boriack-Sjodin, A.P.,Allain, C.,Scott, M.P.,Jin, L.,Raimondi, A.,Handler, J.L.,Ott, H.M.,Kruger, R.G.,McCabe, M.T.,Sneeringer, C.,Riera, T.,Shapiro, G.,Waters, N.J.,Mitchell, L.H.,Duncan, K.W.,Moyer, M.P.,Copeland, R.A.,Smith, J.,Chesworth, R.,Ribich, S.A.; Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.; Sci Rep, 7:17993-17993, 2017; PubMed: 29269946; DOI: 10.1038/s41598-017-18446-z

実験手法

X-RAY DIFFRACTION (2 Å)