6AQS

Crystal structure of Plasmodium falciparum purine nucleoside phosphorylase (V181D) mutant complexed with DADMe-ImmG and phosphate

Summary for 6AQS

Entry DOI	10.2210/pdb6aqs/pdb
Descriptor	Purine nucleoside phosphorylase, PHOSPHATE ION, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, ... (5 entities in total)
Functional Keywords	plasmodium falciparum, purine nucleoside phosphorylase (pnp), phosphorylase, pnp mutant, dadme-immg, transferase
Biological source	Plasmodium falciparum
Total number of polymer chains	1
Total formula weight	27492.59
Authors	Harijan, R.K.,Ducati, R.G.,Namanja-Magliano, H.A.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2017-08-21, release date: 2018-02-14, Last modification date: 2023-10-04)
Primary citation	Ducati, R.G.,Namanja-Magliano, H.A.,Harijan, R.K.,Fajardo, J.E.,Fiser, A.,Daily, J.P.,Schramm, V.L. Genetic resistance to purine nucleoside phosphorylase inhibition in Proc. Natl. Acad. Sci. U.S.A., 115:2114-2119, 2018 Cited by PubMed: 29440412 DOI: 10.1073/pnas.1525670115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.57 Å)

Structure validation