6AQN

Crystal structure of PPK2 in complex with phosphonic acid inhibitor

Summary for 6AQN

• Entry DOI: 10.2210/pdb6aqn/pdb
• Related: 6AN9 6ANG
• Descriptor: Polyphosphate:AMP phosphotransferase, [(R)-hydroxy(4-methylphenyl)methyl]phosphonic acid, GLYCEROL, ... (5 entities in total)
• Functional Keywords: ppk2, kinase, inhibitor, (hydroxy(p-toluyl)methyl)phosphonic acid, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
• Total number of polymer chains: 1
• Total formula weight: 35984.07

Authors

Nocek, B.,Berlicki, l.,Joachimiak, A.,Yakunin, S. (deposition date: 2017-08-20, release date: 2019-01-16, Last modification date: 2023-11-15)

• Primary citation: Nocek, B.,Khusnutdinova, A.N.,Ruszkowski, M.,Flick, R.,Burda, M.,Batyrova, K.,Brown, G.,Mucha, A.,Joachimiak, A.,Berlicki, L.,Yakunin, A.F.; Structural Insights into Substrate Selectivity and Activity of Bacterial Polyphosphate Kinases; Acs Catalysis, 8:10746-10760, 2018; DOI: 10.1021/acscatal.8b03151

Experimental method

X-RAY DIFFRACTION (2.199 Å)