6APS

Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3 diyl)bis(oxy)]bis(methylene))diphosphonic acid

Summary for 6APS

Entry DOI	10.2210/pdb6aps/pdb
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, [{2-[(guanine-9-yl)methyl]propane-1,3-diyl}bis(oxymethylene)]bis(phosphonic acid), MAGNESIUM ION, ... (7 entities in total)
Functional Keywords	trypanosoma brucei, purine salvage, acyclic nucleoside biphosphonate, transferase
Biological source	Trypanosoma brucei brucei
Cellular location	Cytoplasm: Q07010
Total number of polymer chains	2
Total formula weight	49899.24
Authors	Teran, D.,Guddat, L.W. (deposition date: 2017-08-17, release date: 2018-03-14, Last modification date: 2023-10-04)
Primary citation	Dolezelova, E.,Teran, D.,Gahura, O.,Kotrbova, Z.,Prochazkova, M.,Keough, D.,Spacek, P.,Hockova, D.,Guddat, L.,Zikova, A. Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. PLoS Negl Trop Dis, 12:e0006301-e0006301, 2018 Cited by PubMed: 29481567 DOI: 10.1371/journal.pntd.0006301 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.762 Å)

Structure validation