6APS

Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3 diyl)bis(oxy)]bis(methylene))diphosphonic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Hypoxanthine-guanine phosphoribosyltransferase	polymer	216	24221.8	2	UniProt (Q07010) Pfam (PF00156)	Trypanosoma brucei brucei	HGPRTase
2	C, H (A, B)	[{2-[(guanine-9-yl)methyl]propane-1,3-diyl}bis(oxymethylene)]bis(phosphonic acid)	non-polymer		427.2	2	Chemie (SV2)
3	D, I (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	E, J (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
5	F, K (A, B)	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		122.1	2	Chemie (TRS)
6	G (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
7	L, M (A, B)	water	water		18.0	371	Chemie (HOH)

Sequence modifications

A, B: 1 - 210 (UniProt: Q07010)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48443.6
Non-Polymers*	Number of molecules	9
	Total formula weight	1455.7
All*	Total formula weight	49899.2

*Water molecules are not included.