6AOJ

Crystal structure of Legionella pneumophila effector Ceg4 with N-terminal yeast Hog1p sequence

Summary for 6AOJ

Entry DOI	10.2210/pdb6aoj/pdb
Related	6AOK
Descriptor	Ceg4, MAGNESIUM ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	effector, legionella pneumophila, infection, had-like phosphatase, alpha/beta protein, phosphotyrosine, hydrolase
Biological source	Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Total number of polymer chains	1
Total formula weight	24985.35
Authors	Stogios, P.J.,Nocek, B.,Cuff, M.E.,Evdokimova, E.,Egorova, O.,Yim, V.,Di Leo, R.,Savchenko, A. (deposition date: 2017-08-16, release date: 2018-01-10, Last modification date: 2023-10-04)
Primary citation	Quaile, A.T.,Stogios, P.J.,Egorova, O.,Evdokimova, E.,Valleau, D.,Nocek, B.,Kompella, P.S.,Peisajovich, S.,Yakunin, A.F.,Ensminger, A.W.,Savchenko, A. TheLegionella pneumophilaeffector Ceg4 is a phosphotyrosine phosphatase that attenuates activation of eukaryotic MAPK pathways. J. Biol. Chem., 293:3307-3320, 2018 Cited by PubMed: 29301934 DOI: 10.1074/jbc.M117.812727 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.902 Å)

Structure validation