6AO0
CAT192 Fab Insertion Mutant H2/L2
Summary for 6AO0
Entry DOI | 10.2210/pdb6ao0/pdb |
Descriptor | CAT192 Fab Light chain, CAT192 Fab Heavy chain, SULFATE ION, ... (4 entities in total) |
Functional Keywords | fab, tgf-beta, protein engineering, antibody engineering, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 48468.47 |
Authors | Lord, D.M.,Wei, R.R. (deposition date: 2017-08-15, release date: 2018-01-31, Last modification date: 2023-10-04) |
Primary citation | Lord, D.M.,Bird, J.J.,Honey, D.M.,Best, A.,Park, A.,Wei, R.R.,Qiu, H. Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF beta 1 antibody. MAbs, 10:444-452, 2018 Cited by PubMed: 29333938DOI: 10.1080/19420862.2018.1426421 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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