6AN6
Crystal structure of Escherichia coli HPPK in complex with bisubstrate analogue inhibitor HP-72
Summary for 6AN6
Entry DOI | 10.2210/pdb6an6/pdb |
Descriptor | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-{2-[{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}(phosphonomethyl)amino]ethyl}-5'-thioadenosine (3 entities in total) |
Functional Keywords | alpha beta, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Escherichia coli (strain K12) |
Total number of polymer chains | 2 |
Total formula weight | 37298.37 |
Authors | Shaw, G.X.,Shi, G.,Ji, X. (deposition date: 2017-08-12, release date: 2018-08-15, Last modification date: 2023-10-04) |
Primary citation | Shaw, G.X.,Shi, G.,Ji, X. Bisubstrate analogue inhibitors of HPPK: Transition state mimetics to be published, |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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