6AN6

Crystal structure of Escherichia coli HPPK in complex with bisubstrate analogue inhibitor HP-72

Summary for 6AN6

• Entry DOI: 10.2210/pdb6an6/pdb
• Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-{2-[{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}(phosphonomethyl)amino]ethyl}-5'-thioadenosine (3 entities in total)
• Functional Keywords: alpha beta, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Escherichia coli (strain K12)
• Total number of polymer chains: 2
• Total formula weight: 37298.37

Authors

Shaw, G.X.,Shi, G.,Ji, X. (deposition date: 2017-08-12, release date: 2018-08-15, Last modification date: 2023-10-04)

• Primary citation: Shaw, G.X.,Shi, G.,Ji, X.; Bisubstrate analogue inhibitors of HPPK: Transition state mimetics; to be published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)