6AN6

Crystal structure of Escherichia coli HPPK in complex with bisubstrate analogue inhibitor HP-72

6AN6 の概要

• エントリーDOI: 10.2210/pdb6an6/pdb
• 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-{2-[{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}(phosphonomethyl)amino]ethyl}-5'-thioadenosine (3 entities in total)
• 機能のキーワード: alpha beta, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37298.37

構造登録者

Shaw, G.X.,Shi, G.,Ji, X. (登録日: 2017-08-12, 公開日: 2018-08-15, 最終更新日: 2023-10-04)

• 主引用文献: Shaw, G.X.,Shi, G.,Ji, X.; Bisubstrate analogue inhibitors of HPPK: Transition state mimetics; to be published,

実験手法

X-RAY DIFFRACTION (2.3 Å)