6AN2
STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 7.5
Summary for 6AN2
Entry DOI | 10.2210/pdb6an2/pdb |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT, DNA TEMPLATE (5'- D(*AP*TP*GP*AP*AP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... (8 entities in total) |
Functional Keywords | rt, dna, crosslink, n site complex, pyrophosphorolysis, p51, p66, transferase-dna complex, d4t (stavudine), transferase/dna |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 8 |
Total formula weight | 263801.88 |
Authors | Martinez, S.E.,Das, K.,Arnold, E. (deposition date: 2017-08-11, release date: 2018-08-15, Last modification date: 2023-10-04) |
Primary citation | Martinez, S.E.,Bauman, J.D.,Das, K.,Arnold, E. Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes. Protein Sci., 28:587-597, 2019 Cited by PubMed: 30499174DOI: 10.1002/pro.3559 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report