6ALU

Solution structure of a DNA dodecamer with 5-methylcytosine at the 3rd and 8-oxoguanine at the 4th position

Summary for 6ALU

• Entry DOI: 10.2210/pdb6alu/pdb
• NMR Information: BMRB: 30329
• Descriptor: DNA (5'-D(*(DC5)P*GP*(DMC)P*(8OG)P*AP*AP*TP*TP*CP*GP*CP*(DG3))-3') (1 entity in total)
• Functional Keywords: drew-dickerson, dna, non-canonical, modified dna, oxidized dna, dna damage, dna adduct, lesion
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 7226.88

Authors

Gruber, D.R.,Shernyukov, A.V.,Endutkin, A.V.,Bagryanskaya, E.G.,Zharkov, D.O.,Smirnov, S.L. (deposition date: 2017-08-08, release date: 2017-09-06, Last modification date: 2019-11-27)

• Primary citation: Gruber, D.R.,Toner, J.J.,Miears, H.L.,Shernyukov, A.V.,Kiryutin, A.S.,Lomzov, A.A.,Endutkin, A.V.,Grin, I.R.,Petrova, D.V.,Kupryushkin, M.S.,Yurkovskaya, A.V.,Johnson, E.C.,Okon, M.,Bagryanskaya, E.G.,Zharkov, D.O.,Smirnov, S.L.; Oxidative damage to epigenetically methylated sites affects DNA stability, dynamics and enzymatic demethylation.; Nucleic Acids Res., 46:10827-10839, 2018; PubMed: 30289469; DOI: 10.1093/nar/gky893

Experimental method

SOLUTION NMR