6AKH

Pre-catalytic Ternary Complex of Human DNA Polymerase Mu with Templating Adenine and Incoming Mn-dUMPNPP

Summary for 6AKH

• Entry DOI: 10.2210/pdb6akh/pdb
• Descriptor: DNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ... (10 entities in total)
• Functional Keywords: dna polymerase mu, dna break repair, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 46450.70

Authors

Chang, Y.K.,Wu, W.J.,Tsai, M.D. (deposition date: 2018-08-31, release date: 2019-05-29, Last modification date: 2024-03-27)

• Primary citation: Chang, Y.K.,Huang, Y.P.,Liu, X.X.,Ko, T.P.,Bessho, Y.,Kawano, Y.,Maestre-Reyna, M.,Wu, W.J.,Tsai, M.D.; Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.; J.Am.Chem.Soc., 141:8489-8502, 2019; PubMed: 31067051; DOI: 10.1021/jacs.9b01741

Experimental method

X-RAY DIFFRACTION (1.75 Å)