6AJG

Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with SQ109

Summary for 6AJG

Entry DOI	10.2210/pdb6ajg/pdb
Descriptor	Drug exporters of the RND superfamily-like protein,Endolysin, N-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, DODECYL-BETA-D-MALTOSIDE, ... (4 entities in total)
Functional Keywords	membrane protein, transporter, rnd family, cell wall biosynthesis, drug target, hydrolase
Biological source	Mycobacterium smegmatis str. MC2 155 More
Total number of polymer chains	1
Total formula weight	109314.03
Authors	Zhang, B.,Li, J.,Yang, X.L.,Wu, L.J.,Yang, H.T.,Rao, Z.H. (deposition date: 2018-08-27, release date: 2018-12-26, Last modification date: 2023-11-22)
Primary citation	Zhang, B.,Li, J.,Yang, X.,Wu, L.,Zhang, J.,Yang, Y.,Zhao, Y.,Zhang, L.,Yang, X.,Yang, X.,Cheng, X.,Liu, Z.,Jiang, B.,Jiang, H.,Guddat, L.W.,Yang, H.,Rao, Z. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell, 176:636-648.e13, 2019 Cited by PubMed: 30682372 DOI: 10.1016/j.cell.2019.01.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.604 Å)

Structure validation