6AGX

The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold

Summary for 6AGX

• Entry DOI: 10.2210/pdb6agx/pdb
• Descriptor: Fibroblast growth factor receptor 2, ethyl [4-({3-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazin-5-yl}sulfonyl)-1H-imidazol-1-yl]acetate (2 entities in total)
• Functional Keywords: tyrosine-protein kinase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 140196.14

Authors

Xiong, B. (deposition date: 2018-08-15, release date: 2019-08-21, Last modification date: 2023-11-22)

• Primary citation: Xiong, B.; The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold; To be published,

Experimental method

X-RAY DIFFRACTION (2.95 Å)