6AGK

The structure of CH-II-77-tubulin complex

6AGK の概要

• エントリーDOI: 10.2210/pdb6agk/pdb
• 分子名称: Tubulin alpha-1B chain, [6-(3-hydroxy-4-methylphenyl)pyridin-2-yl](3,4,5-trimethoxyphenyl)methanone, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: tubulin, complex, inhibitor, structural protein
• 由来する生物種: Sus scrofa (Pig); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265165.36

構造登録者

Chen, H.,Arnst, K.,Wang, Y.,Miller, D.,Li, W. (登録日: 2018-08-13, 公開日: 2019-08-21, 最終更新日: 2023-11-22)

• 主引用文献: Chen, H.,Deng, S.,Wang, Y.,Albadari, N.,Kumar, G.,Ma, D.,Li, W.,White, S.W.,Miller, D.D.,Li, W.; Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.; J.Med.Chem., 63:827-846, 2020; PubMed: 31860298; DOI: 10.1021/acs.jmedchem.9b01815

実験手法

X-RAY DIFFRACTION (2.8 Å)