6AFR
Crystal Structure of the first bromodomain of human BRD4 in complex with 5-((4-fluoro-1H-imidazol-1-yl)methyl)quinolin-8-ol
Summary for 6AFR
Entry DOI | 10.2210/pdb6afr/pdb |
Descriptor | Bromodomain-containing protein 4, 5-[(4-fluoranylimidazol-1-yl)methyl]quinolin-8-ol (3 entities in total) |
Functional Keywords | brd4, epigenetic, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15342.62 |
Authors | Xing, J.,Zhang, R.K.,Zheng, M.Y.,Luo, C.,Jiang, X.R. (deposition date: 2018-08-08, release date: 2018-12-12, Last modification date: 2024-03-27) |
Primary citation | Xing, J.,Zhang, R.,Jiang, X.,Hu, T.,Wang, X.,Qiao, G.,Wang, J.,Yang, F.,Luo, X.,Chen, K.,Shen, J.,Luo, C.,Jiang, H.,Zheng, M. Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors Eur J Med Chem, 163:281-294, 2018 Cited by PubMed: 30529546DOI: 10.1016/j.ejmech.2018.11.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.998 Å) |
Structure validation
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