6AFN

Crystal structure of class A b-lactamase, PenL, variant Cys69Tyr, from Burkholderia thailandensis, in complex with ceftazidime-like boronic acid

6AFN の概要

• エントリーDOI: 10.2210/pdb6afn/pdb
• 分子名称: Beta-lactamase, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: extended-spectrum beta-lactam, cys69tyr, penl, burkhodelria, ceftazidime-like boronic acid hydrolase, hydrolase
• 由来する生物種: Burkholderia thailandensis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29159.71

構造登録者

Cao, T.-P.,Choi, J.M.,Lee, S.H. (登録日: 2018-08-08, 公開日: 2020-01-15, 最終更新日: 2023-11-22)

• 主引用文献: Cao, T.-P.,Yi, H.,Dhanasingh, I.,Ghosh, S.,Choi, J.M.,Lee, K.H.,Ryu, S.,Kim, H.S.,Lee, S.H.; Non-catalytic-Region Mutations Conferring Transition of Class A beta-Lactamases Into ESBLs.; Front Mol Biosci, 2020; DOI: 10.3389/fmolb.2020.598998

実験手法

X-RAY DIFFRACTION (1.4 Å)