6AFK
Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor
Summary for 6AFK
Entry DOI | 10.2210/pdb6afk/pdb |
Descriptor | tRNA (guanine-N(1)-)-methyltransferase, S-ADENOSYLMETHIONINE, N-{(3S)-1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl}-1H-indole-2-carboxamide, ... (4 entities in total) |
Functional Keywords | trna methyltransferase, transferase |
Biological source | Pseudomonas aeruginosa UCBPP-PA14 |
Total number of polymer chains | 2 |
Total formula weight | 61457.21 |
Authors | Zhong, W.,Koay, A.,Wong, Y.W.,Sahili, A.E.,Nah, Q.,Kang, C.,Poulsen, A.,Chionh, Y.K.,McBee, M.,Matter, A.,Hill, J.,Lescar, J.,Dedon, P.C. (deposition date: 2018-08-08, release date: 2019-08-14, Last modification date: 2023-11-22) |
Primary citation | Zhong, W.,Koay, A.,Ngo, A.,Li, Y.,Nah, Q.,Wong, Y.H.,Chionh, Y.H.,Ng, H.Q.,Koh-Stenta, X.,Poulsen, A.,Foo, K.,McBee, M.,Choong, M.L.,El Sahili, A.,Kang, C.,Matter, A.,Lescar, J.,Hill, J.,Dedon, P. Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors. Acs Infect Dis., 5:326-335, 2019 Cited by PubMed: 30682246DOI: 10.1021/acsinfecdis.8b00275 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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