6AE3
Crystal structure of GSK3beta complexed with Morin
Summary for 6AE3
| Entry DOI | 10.2210/pdb6ae3/pdb |
| Descriptor | Glycogen synthase kinase-3 beta, 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | kinase, flavonoid, signaling protein |
| Biological source | Mus musculus (Mouse) |
| Total number of polymer chains | 4 |
| Total formula weight | 188361.58 |
| Authors | |
| Primary citation | Kim, K.,Cha, J.S.,Kim, J.S.,Ahn, J.,Ha, N.C.,Cho, H.S. Crystal structure of GSK3 beta in complex with the flavonoid, morin Biochem. Biophys. Res. Commun., 504:519-524, 2018 Cited by PubMed Abstract: GSK3β is a key kinase that plays a role in cellular signaling pathways. In Alzheimer's disease (AD), GSK3β has been implicated in hyperphosphorylation of tau proteins in the neuron, which is a hallmark of AD. Morin, a flavonoid that is abundant in nature, was found as an inhibitor of GSK3β that can reduce tau pathology in vivo and in vitro. In this study, we determined the crystal structure of GSK3β in complex with morin. The structure revealed that morin inhibits GSK3β by binding to the ATP binding pocket. Our findings augment the potential of morin as a functional food to help prevent AD, as well as to provide structural information to develop new therapeutics based on the morin skeleton. PubMed: 30197003DOI: 10.1016/j.bbrc.2018.08.182 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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