6AE3

Crystal structure of GSK3beta complexed with Morin

6AE3 の概要

• エントリーDOI: 10.2210/pdb6ae3/pdb
• 分子名称: Glycogen synthase kinase-3 beta, 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: kinase, flavonoid, signaling protein
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 188361.58

構造登録者

Kim, K.L.,Cha, J.S.,Kim, J.S.,Ahn, J.S.,Ha, N.C.,Cho, H.S. (登録日: 2018-08-03, 公開日: 2018-09-19, 最終更新日: 2024-11-20)

主引用文献

Kim, K.,Cha, J.S.,Kim, J.S.,Ahn, J.,Ha, N.C.,Cho, H.S.
Crystal structure of GSK3 beta in complex with the flavonoid, morin
Biochem. Biophys. Res. Commun., 504:519-524, 2018

PubMed Abstract: GSK3β is a key kinase that plays a role in cellular signaling pathways. In Alzheimer's disease (AD), GSK3β has been implicated in hyperphosphorylation of tau proteins in the neuron, which is a hallmark of AD. Morin, a flavonoid that is abundant in nature, was found as an inhibitor of GSK3β that can reduce tau pathology in vivo and in vitro. In this study, we determined the crystal structure of GSK3β in complex with morin. The structure revealed that morin inhibits GSK3β by binding to the ATP binding pocket. Our findings augment the potential of morin as a functional food to help prevent AD, as well as to provide structural information to develop new therapeutics based on the morin skeleton.

PubMed: 30197003
DOI: 10.1016/j.bbrc.2018.08.182

実験手法

X-RAY DIFFRACTION (2.14 Å)