6ADI

Crystal Structures of IDH2 R140Q in complex with AG-881

Summary for 6ADI

Entry DOI	10.2210/pdb6adi/pdb
Descriptor	Isocitrate dehydrogenase [NADP], mitochondrial, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-(6-chloropyridin-2-yl)-N2,N4-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine, ... (4 entities in total)
Functional Keywords	oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	96988.02
Authors	Ma, R.,Yun, C.H. (deposition date: 2018-08-01, release date: 2018-09-05, Last modification date: 2023-11-22)
Primary citation	Ma, R.,Yun, C.H. Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2 Biochem. Biophys. Res. Commun., 503:2912-2917, 2018 Cited by PubMed: 30131249 DOI: 10.1016/j.bbrc.2018.08.068 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.969 Å)

Structure validation