6A7C

Human dihydrofolate reductase complexed with NADPH and BT1

Summary for 6A7C

Entry DOI	10.2210/pdb6a7c/pdb
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine, ... (5 entities in total)
Functional Keywords	dhfr, antifolate, inhibitor, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	22807.63
Authors	Vanichtanankul, J.,Tarnchompoo, B.,Chitnumsub, P.,Kamchonwongpaisan, S.,Yuthavong, Y. (deposition date: 2018-07-02, release date: 2019-04-10, Last modification date: 2023-11-22)
Primary citation	Tarnchompoo, B.,Chitnumsub, P.,Jaruwat, A.,Shaw, P.J.,Vanichtanankul, J.,Poen, S.,Rattanajak, R.,Wongsombat, C.,Tonsomboon, A.,Decharuangsilp, S.,Anukunwithaya, T.,Arwon, U.,Kamchonwongpaisan, S.,Yuthavong, Y. Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance. ACS Med Chem Lett, 9:1235-1240, 2018 Cited by PubMed: 30613332 DOI: 10.1021/acsmedchemlett.8b00389 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.06 Å)

Structure validation