6A79
Crystal structure of the fifth immunoglobulin domain (Ig5) of human Robo1 in complex with the mutant scFv fragment (P103A) of murine monoclonal antibody B5209B
Summary for 6A79
Entry DOI | 10.2210/pdb6a79/pdb |
Descriptor | Roundabout homolog 1, Light chain region of the anti-human Robo1 antibody B5209B scFv, Heavy chain of the anti-human Robo1 antibody B5209B scFv, ... (5 entities in total) |
Functional Keywords | hepatocellular carcinoma antigen, angiogenesis, immune system, antibody drug, single-chain variable fragment |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 72440.59 |
Authors | Mizohata, E.,Nakayama, T.,Kado, Y.,Yokota, Y.,Inoue, T. (deposition date: 2018-07-02, release date: 2019-01-30, Last modification date: 2019-03-20) |
Primary citation | Yamashita, T.,Mizohata, E.,Nagatoishi, S.,Watanabe, T.,Nakakido, M.,Iwanari, H.,Mochizuki, Y.,Nakayama, T.,Kado, Y.,Yokota, Y.,Matsumura, H.,Kawamura, T.,Kodama, T.,Hamakubo, T.,Inoue, T.,Fujitani, H.,Tsumoto, K. Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface. Structure, 27:519-, 2019 Cited by PubMed: 30595454DOI: 10.1016/j.str.2018.11.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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