6A78

Crystal structure of the fifth immunoglobulin domain (Ig5) of human Robo1 in complex with the scFv fragment of murine monoclonal antibody B5209B

Summary for 6A78

Entry DOI	10.2210/pdb6a78/pdb
Descriptor	Roundabout homolog 1, Light chain region of the anti-human Robo1 antibody B5209B scFv, Heavy chain and linker region of the anti-human Robo1 antibody B5209B scFv, ... (5 entities in total)
Functional Keywords	hepatocellular carcinoma antigen, angiogenesis, immune system, antibody drug, single chain fv fragment
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	72492.66
Authors	Mizohata, E.,Nakayama, T.,Kado, Y.,Inoue, T. (deposition date: 2018-07-02, release date: 2019-01-30, Last modification date: 2019-03-20)
Primary citation	Yamashita, T.,Mizohata, E.,Nagatoishi, S.,Watanabe, T.,Nakakido, M.,Iwanari, H.,Mochizuki, Y.,Nakayama, T.,Kado, Y.,Yokota, Y.,Matsumura, H.,Kawamura, T.,Kodama, T.,Hamakubo, T.,Inoue, T.,Fujitani, H.,Tsumoto, K. Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface. Structure, 27:519-, 2019 Cited by PubMed: 30595454 DOI: 10.1016/j.str.2018.11.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation