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6A60

Crystal structure of human FXR/RXR-LBD heterodimer bound to GW4064 and 9cRA and SRC1

Summary for 6A60
Entry DOI10.2210/pdb6a60/pdb
Related6A5W 6A5X 6A5Y 6A5Z
DescriptorBile acid receptor, Nuclear receptor coactivator 1, Retinoic acid receptor RXR-alpha, ... (6 entities in total)
Functional Keywordsnuclear receptor heterodimer, transcription
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight58176.23
Authors
Wang, N.,Liu, J. (deposition date: 2018-06-25, release date: 2018-10-10, Last modification date: 2024-03-27)
Primary citationWang, N.,Zou, Q.,Xu, J.,Zhang, J.,Liu, J.
Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
J. Biol. Chem., 293:18180-18191, 2018
Cited by
PubMed: 30275017
DOI: 10.1074/jbc.RA118.004652
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.05 Å)
Structure validation

217705

数据于2024-03-27公开中

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