6A5Y

Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC143 and 9cRA and SRC1

Summary for 6A5Y

Entry DOI	10.2210/pdb6a5y/pdb
Descriptor	Bile acid receptor, Nuclear receptor coactivator 1, Retinoic acid receptor RXR-alpha, ... (8 entities in total)
Functional Keywords	nuclear receptor, heterodimer, complex, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	58362.85
Authors	Wang, N.,Liu, J. (deposition date: 2018-06-25, release date: 2018-10-10, Last modification date: 2024-03-27)
Primary citation	Wang, N.,Zou, Q.,Xu, J.,Zhang, J.,Liu, J. Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293:18180-18191, 2018 Cited by PubMed: 30275017 DOI: 10.1074/jbc.RA118.004652 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation