6A5Y
Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC143 and 9cRA and SRC1
Summary for 6A5Y
Entry DOI | 10.2210/pdb6a5y/pdb |
Descriptor | Bile acid receptor, Nuclear receptor coactivator 1, Retinoic acid receptor RXR-alpha, ... (8 entities in total) |
Functional Keywords | nuclear receptor, heterodimer, complex, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 58362.85 |
Authors | |
Primary citation | Wang, N.,Zou, Q.,Xu, J.,Zhang, J.,Liu, J. Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293:18180-18191, 2018 Cited by PubMed: 30275017DOI: 10.1074/jbc.RA118.004652 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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