6A5W

FXR-LBD with HNC143 and SRC1

Summary for 6A5W

Entry DOI	10.2210/pdb6a5w/pdb
Descriptor	Bile acid receptor, Nuclear receptor coactivator 1, 2-[2-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-6-azaspiro[3.4]octan-6-yl]-1,3-benzothiazole-6-carboxylic acid, ... (4 entities in total)
Functional Keywords	nuclear receptor, coactivator, agonist, complex, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	57657.64
Authors	Wang, N.,Liu, J. (deposition date: 2018-06-25, release date: 2018-10-10, Last modification date: 2023-11-22)
Primary citation	Wang, N.,Zou, Q.,Xu, J.,Zhang, J.,Liu, J. Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293:18180-18191, 2018 Cited by PubMed: 30275017 DOI: 10.1074/jbc.RA118.004652 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.88 Å)

Structure validation