6A5W

FXR-LBD with HNC143 and SRC1

6A5W の概要

• エントリーDOI: 10.2210/pdb6a5w/pdb
• 分子名称: Bile acid receptor, Nuclear receptor coactivator 1, 2-[2-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-6-azaspiro[3.4]octan-6-yl]-1,3-benzothiazole-6-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, coactivator, agonist, complex, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 57657.64

構造登録者

Wang, N.,Liu, J. (登録日: 2018-06-25, 公開日: 2018-10-10, 最終更新日: 2023-11-22)

• 主引用文献: Wang, N.,Zou, Q.,Xu, J.,Zhang, J.,Liu, J.; Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding; J. Biol. Chem., 293:18180-18191, 2018; PubMed: 30275017; DOI: 10.1074/jbc.RA118.004652

実験手法

X-RAY DIFFRACTION (2.88 Å)