6ZVF

Crystal structure of the recombinant Fab fragment derived from the hybridoma M3/38 in complex with a human Galectin-3 peptide

Summary for 6ZVF

Entry DOI	10.2210/pdb6zvf/pdb
Descriptor	Chimeric Fab M3/38 (L,H), Galectin-3, ... (4 entities in total)
Functional Keywords	antibody, fab fragment, peptide epitope, protein engineering, immune system
Biological source	Rattus norvegicus More
Total number of polymer chains	3
Total formula weight	49203.38
Authors	Skerra, A.,Eichinger, A. (deposition date: 2020-07-24, release date: 2021-04-14, Last modification date: 2024-01-31)
Primary citation	Peplau, E.,De Rose, F.,Eichinger, A.,Reder, S.,Mittelhauser, M.,Scafetta, G.,Schwaiger, M.,Weber, W.A.,Bartolazzi, A.,D'Alessandria, C.,Skerra, A. Effective rational humanization of a PASylated anti-galectin-3 Fab for the sensitive PET imaging of thyroid cancer in vivo. Sci Rep, 11:7358-7358, 2021 Cited by PubMed: 33795750 DOI: 10.1038/s41598-021-86641-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation