6ZRG

Crystal structure of OXA-10loop48 in complex with hydrolyzed doripenem

Summary for 6ZRG

• Entry DOI: 10.2210/pdb6zrg/pdb
• Descriptor: Beta-lactamase, (4R,5S)-3-{[(3S,5S)-5-({[amino(dihydroxy)methyl]amino}methyl)pyrrolidin-3-yl]sulfanyl}-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: beta-lactamase, oxa-10loop48, carbapenem, doripenem, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 56157.29

Authors

Tassone, G.,Di Pisa, F.,Benvenuti, M.,De Luca, F.,Pozzi, C.,Docquier, J.D.,Mangani, S. (deposition date: 2020-07-13, release date: 2021-07-21, Last modification date: 2024-01-31)

• Primary citation: Tassone, G.,Di Pisa, F.,Benvenuti, M.,De Luca, F.,Pozzi, C.,Docquier, J.D.,Mangani, S.; Mechanistic insights into carbapenem hydrolysis by OXA-48 and the OXA10-derived hybrids OXA-10 loop24 and loop48; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.74 Å)