6ZR8
The crystal structure of 2-(4-Benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide in complex with human carbonic anhydrase II
Summary for 6ZR8
Entry DOI | 10.2210/pdb6zr8/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 2-[4-(diphenylmethyl)piperazin-1-yl]-~{N}-(4-sulfamoylphenyl)ethanamide, ... (4 entities in total) |
Functional Keywords | protein-inhibitor adduct, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 30007.30 |
Authors | Di Fiore, A.,De Simone, G.,D'Ambrosio, K. (deposition date: 2020-07-11, release date: 2021-06-16, Last modification date: 2024-01-31) |
Primary citation | D'Ambrosio, K.,Di Fiore, A.,Buonanno, M.,Kumari, S.,Tiwari, M.,Supuran, C.T.,Mishra, C.B.,Monti, S.M.,De Simone, G. The crystal structures of 2-(4-benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide in complex with human carbonic anhydrase II and VII provide insights into selective CA inhibitor development New J.Chem., 45:147-152, 2021 Cited by DOI: 10.1039/D0NJ03544KPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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