6YT2
Crystal Structure of human monoamine oxidase B in complex with Diphenylene iodonium (DPI)
Summary for 6YT2
Entry DOI | 10.2210/pdb6yt2/pdb |
Descriptor | Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, benzo[b][1]benziodole, ... (6 entities in total) |
Functional Keywords | monoamine oxidase, drug target, neurodegeneration, ros, flavin, mitochondrial membrane, flavoprotein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 120399.65 |
Authors | Iacovino, L.G.,Reis, J.,Mai, A.,Mattevi, A.,Binda, C. (deposition date: 2020-04-23, release date: 2020-06-10, Last modification date: 2024-01-24) |
Primary citation | Iacovino, L.G.,Reis, J.,Mai, A.,Binda, C.,Mattevi, A. Diphenylene Iodonium Is a Noncovalent MAO Inhibitor: A Biochemical and Structural Analysis. Chemmedchem, 15:1394-1397, 2020 Cited by PubMed: 32459875DOI: 10.1002/cmdc.202000264 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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