6YQ0
Promiscuous Reductase LugOII Catalyzes Keto-reduction at C1 during Lugdunomycin Biosynthesis
This is a non-PDB format compatible entry.
Summary for 6YQ0
Entry DOI | 10.2210/pdb6yq0/pdb |
Descriptor | Monooxygenase, 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | lugdunomycin, keto-reduction, short chain alcohol reductase, rossmann fold, antibiotic |
Biological source | Streptomyces sp. QL37 |
Total number of polymer chains | 2 |
Total formula weight | 56622.93 |
Authors | Xiao, X.,Elsayed, S.S.,Wu, C.,van der Heul, H.,Prota, A.,Huang, J.,Guo, R.,Abrahams, J.P.,van Wezel, G.P. (deposition date: 2020-04-16, release date: 2020-09-16, Last modification date: 2024-01-24) |
Primary citation | Xiao, X.,Elsayed, S.S.,Wu, C.,van der Heul, H.U.,Metsa-Ketela, M.,Du, C.,Prota, A.E.,Chen, C.C.,Liu, W.,Guo, R.T.,Abrahams, J.P.,van Wezel, G.P. Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway. Acs Chem.Biol., 15:2529-2538, 2020 Cited by PubMed: 32840360DOI: 10.1021/acschembio.0c00564 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.08 Å) |
Structure validation
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