6YM5
Crystal structure of BAY-091 with PIP4K2A
Summary for 6YM5
Entry DOI | 10.2210/pdb6ym5/pdb |
Descriptor | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, PHOSPHATE ION, (2~{R})-2-[[3-cyano-2-[4-(2-fluoranyl-3-methyl-phenyl)phenyl]-1,7-naphthyridin-4-yl]amino]butanoic acid, ... (4 entities in total) |
Functional Keywords | pip4k2a, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 91696.85 |
Authors | Holton, S.J.,Wortmann, L.,Braeuer, N.,Irlbacher, H.,Weiske, J.,Lechner, C.,Meier, R.,Puetter, V.,Christ, C.,ter Laak, T.,Lienau, P.,Lesche, R.,Nicke, B.,Bauser, M.,Haegebarth, A.,von Nussbaum, F.,Mumberg, D.,Lemos, C. (deposition date: 2020-04-07, release date: 2021-04-14, Last modification date: 2024-01-24) |
Primary citation | Wortmann, L.,Brauer, N.,Holton, S.J.,Irlbacher, H.,Weiske, J.,Lechner, C.,Meier, R.,Karen, J.,Sioberg, C.B.,Putter, V.,Christ, C.D.,Ter Laak, A.,Lienau, P.,Lesche, R.,Nicke, B.,Cheung, S.H.,Bauser, M.,Haegebarth, A.,von Nussbaum, F.,Mumberg, D.,Lemos, C. Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A. J.Med.Chem., 64:15883-15911, 2021 Cited by PubMed: 34699202DOI: 10.1021/acs.jmedchem.1c01245 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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