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6YM5

Crystal structure of BAY-091 with PIP4K2A

Functional Information from GO Data
ChainGOidnamespacecontents
A0001750cellular_componentphotoreceptor outer segment
A0001917cellular_componentphotoreceptor inner segment
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005776cellular_componentautophagosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0010506biological_processregulation of autophagy
A0016301molecular_functionkinase activity
A0016308molecular_function1-phosphatidylinositol-4-phosphate 5-kinase activity
A0016309molecular_function1-phosphatidylinositol-5-phosphate 4-kinase activity
A0035855biological_processmegakaryocyte development
A0042803molecular_functionprotein homodimerization activity
A0042995cellular_componentcell projection
A0046488biological_processphosphatidylinositol metabolic process
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
A0052742molecular_functionphosphatidylinositol kinase activity
A0061909biological_processautophagosome-lysosome fusion
A0090119biological_processvesicle-mediated cholesterol transport
A1902635biological_process1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
A2000786biological_processpositive regulation of autophagosome assembly
B0001750cellular_componentphotoreceptor outer segment
B0001917cellular_componentphotoreceptor inner segment
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005776cellular_componentautophagosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0010506biological_processregulation of autophagy
B0016301molecular_functionkinase activity
B0016308molecular_function1-phosphatidylinositol-4-phosphate 5-kinase activity
B0016309molecular_function1-phosphatidylinositol-5-phosphate 4-kinase activity
B0035855biological_processmegakaryocyte development
B0042803molecular_functionprotein homodimerization activity
B0042995cellular_componentcell projection
B0046488biological_processphosphatidylinositol metabolic process
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046854biological_processphosphatidylinositol phosphate biosynthetic process
B0052742molecular_functionphosphatidylinositol kinase activity
B0061909biological_processautophagosome-lysosome fusion
B0090119biological_processvesicle-mediated cholesterol transport
B1902635biological_process1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
B2000786biological_processpositive regulation of autophagosome assembly
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue PO4 A 501
ChainResidue
APHD359
ATHR362
AOZ5502
AHOH645

site_idAC2
Number of Residues16
Detailsbinding site for residue OZ5 A 502
ChainResidue
APHE178
AILE194
AASN198
AVAL199
ALYS209
ATHR232
ALEU277
AILE358
APO4501
AHOH635
AHOH652
APHE134
AILE143
ALYS145
AILE147
AASP151

site_idAC3
Number of Residues3
Detailsbinding site for residue PO4 B 501
ChainResidue
BASP151
BPHD359
BOZ5502

site_idAC4
Number of Residues14
Detailsbinding site for residue OZ5 B 502
ChainResidue
BPHE134
BILE143
BLYS145
BILE147
BMET155
BILE194
BASN198
BVAL199
BLYS209
BTHR232
BLEU277
BILE358
BPO4501
BHOH615

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS89
ALYS145
BLYS89
BLYS145

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PDB entries from 2024-07-24

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