6YLT

Translation initiation factor 4E in complex with 3-MeBn7GpppG mRNA 5' cap analog

Summary for 6YLT

Entry DOI	10.2210/pdb6ylt/pdb
Descriptor	Eukaryotic translation initiation factor 4E, [[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-methylphenyl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate (3 entities in total)
Functional Keywords	cap analog, translation initiation factor, 3-mebn7gpppg, protein-ligand complex, eif4e, translation
Biological source	Mus musculus (Mouse)
Total number of polymer chains	4
Total formula weight	92679.49
Authors	Kubacka, D.,Wojcik, R.,Baranowski, M.R.,Kowalska, J.,Jemielity, J. (deposition date: 2020-04-07, release date: 2020-04-29, Last modification date: 2024-01-24)
Primary citation	Wojcik, R.,Baranowski, M.R.,Markiewicz, L.,Kubacka, D.,Bednarczyk, M.,Baran, N.,Wojtczak, A.,Sikorski, P.J.,Zuberek, J.,Kowalska, J.,Jemielity, J. Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation. Pharmaceutics, 13:-, 2021 Cited by PubMed: 34834356 DOI: 10.3390/pharmaceutics13111941 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.67 Å)

Structure validation