6YJS

Crystal structure of MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V) luminal domain with a Lys329-Ile345 loop truncation, in complex with biantennary pentasaccharide M592

This is a non-PDB format compatible entry.

Summary for 6YJS

• Entry DOI: 10.2210/pdb6yjs/pdb
• Descriptor: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: transferase, carbohydrate, enzyme, n-glycosylation, glcnac
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 121901.25

Authors

Wu, L.,Darby, J.F.,Gilio, A.K.,Davies, G.J. (deposition date: 2020-04-04, release date: 2020-08-05, Last modification date: 2024-11-20)

• Primary citation: Darby, J.F.,Gilio, A.K.,Piniello, B.,Roth, C.,Blagova, E.,Rovira, C.,Hubbard, R.E.,Davies, G.J.,Wu, L.; Substrate Engagement and Catalytic Mechanisms of N-Acetylglucosaminyltransferase V; Acs Catalysis, 2020; DOI: 10.1021/acscatal.0c02222

Experimental method

X-RAY DIFFRACTION (1.6 Å)