6YJS

Crystal structure of MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V) luminal domain with a Lys329-Ile345 loop truncation, in complex with biantennary pentasaccharide M592

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (AAA, BBB)	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A	polymer	515	58996.9	2	UniProt (Q09328) Pfam (PF15024)	Homo sapiens (Human)	Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase V,GlcNAc-T V,GNT-V,Mannoside acetylglucosaminyltransferase 5,N-acetylglucosaminyl-transferase V
2	C, D (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose	branched		910.8	2	In PDB GlyTouCan (G19266OP)
3	E, F, G, N, O... (AAA, BBB)	1,2-ETHANEDIOL	non-polymer		62.1	11	Chemie (EDO)
4	H, R (AAA, BBB)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	AA, I, J, K, L... (BBB, AAA)	SULFATE ION	non-polymer		96.1	10	Chemie (SO4)
6	BA, CA (AAA, BBB)	water	water		18.0	466	Chemie (HOH)

Sequence modifications

AAA, BBB: 214 - 728 (UniProt: Q09328)

PDB	External Database	Details
-	Lys 329	deletion
-	Lys 330	deletion
-	Val 331	deletion
-	Val 332	deletion
-	Gly 333	deletion
-	Asn 334	deletion
-	Arg 335	deletion
-	Ser 336	deletion
-	Gly 337	deletion
-	Cys 338	deletion
-	Pro 339	deletion
-	Thr 340	deletion
-	Val 341	deletion
Gly 330	Asp 343	conflict
Gly 331	Arg 344	conflict
Gly 332	Ile 345	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	117993.8
Branched	Number of molecules	2
	Total formula weight	1821.6
Non-Polymers*	Number of molecules	23
	Total formula weight	2085.8
All*	Total formula weight	121901.3

*Water molecules are not included.