6YAT
Crystal structure of STK4 (MST1) in complex with compound 6
Summary for 6YAT
Entry DOI | 10.2210/pdb6yat/pdb |
Descriptor | Serine/threonine-protein kinase 4, (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, GLYCEROL, ... (5 entities in total) |
Functional Keywords | kinase, kinase inhibitor, mst1, stk4, hippo pathway, chemical probe, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 73135.32 |
Authors | Chaikuad, A.,Bata, N.,Limpert, A.S.,Lambert, L.J.,Bakas, N.A.,Cosford, N.D.P.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-03-13, release date: 2020-04-29, Last modification date: 2024-01-24) |
Primary citation | Bata, N.,Chaikuad, A.,Bakas, N.A.,Limpert, A.S.,Lambert, L.J.,Sheffler, D.J.,Berger, L.M.,Liu, G.,Yuan, C.,Wang, L.,Peng, Y.,Dong, J.,Celeridad, M.,Layng, F.,Knapp, S.,Cosford, N.D.P. Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia. J.Med.Chem., 65:1352-1369, 2022 Cited by PubMed: 34807584DOI: 10.1021/acs.jmedchem.1c00804 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.58 Å) |
Structure validation
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