6Y9R

Crystal structure of GSK-3b in complex with the 1H-indazole-3-carboxamide inhibitor 2

Summary for 6Y9R

Entry DOI	10.2210/pdb6y9r/pdb
Descriptor	Glycogen synthase kinase-3 beta, ~{N}-[[1-(2-methoxyethyl)piperidin-4-yl]methyl]-5-(5-propan-2-yloxypyridin-3-yl)-1~{H}-indazole-3-carboxamide, ACETATE ION, ... (5 entities in total)
Functional Keywords	glycogen synthase kinase-3 beta, indazole, inhibitor, kinase, transferase, proteros biostructures gmbh
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40577.57
Authors	Krapp, S.,Griessner, A.,Blaesse, M.,Buonfiglio, R.,Ombrato, R. (deposition date: 2020-03-10, release date: 2020-05-20, Last modification date: 2020-07-08)
Primary citation	Buonfiglio, R.,Prati, F.,Bischetti, M.,Cavarischia, C.,Furlotti, G.,Ombrato, R. Discovery of Novel Imidazopyridine GSK-3 beta Inhibitors Supported by Computational Approaches. Molecules, 25:-, 2020 Cited by PubMed: 32380735 DOI: 10.3390/molecules25092163 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08 Å)

Structure validation