6Y4T
Crystal structure of p38 in complex with SR63.
Summary for 6Y4T
Entry DOI | 10.2210/pdb6y4t/pdb |
Descriptor | Mitogen-activated protein kinase 14, 5-azanyl-~{N}-[[4-[[(2~{S})-1-[[(2~{S})-butan-2-yl]amino]-4-cyclohexyl-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | kinase, kinase inhibitor, mapk, mapk14, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Mus musculus (House mouse) |
Total number of polymer chains | 1 |
Total formula weight | 42388.40 |
Authors | Chaikuad, A.,Roehm, S.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-02-23, release date: 2020-03-04, Last modification date: 2024-01-24) |
Primary citation | Rohm, S.,Schroder, M.,Dwyer, J.E.,Widdowson, C.S.,Chaikuad, A.,Berger, B.T.,Joerger, A.C.,Kramer, A.,Harbig, J.,Dauch, D.,Kudolo, M.,Laufer, S.,Bagley, M.C.,Knapp, S. Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208:112721-112721, 2020 Cited by PubMed: 33035818DOI: 10.1016/j.ejmech.2020.112721 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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